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5 OMIM references -
4 associated genes
11 signs/symptoms

PROTEIN INTERACTIONS: 2

Bladder exstrophy

1 OMIM reference -
1 associated gene
14 signs/symptoms

Nephroblastoma

Bladder exstrophy

DIS3L2	(UniProt - OMIM)		TP63	(UniProt - OMIM)
H19	(OMIM)
POU6F2	(UniProt - OMIM)
WT1	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	H19 WT1	(0.63) (0.55)	TP63 TP63

Citations in the biomedical literature:

Nephroblastoma		Bladder exstrophy
	Synonym(s): - Renal embryonic tumor - Wilms tumor		Synonym(s): - Classic exstrophy of the bladder

	Classification (Orphanet): - Rare genetic disease		Classification (Orphanet): - Rare abdominal surgical disease - Rare developmental defect during embryogenesis - Rare genetic disease - Rare renal disease - Rare urogenital disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: childhood Average age of death: any age Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: neonatal/infancy Average age of death: normal Type of inheritance: multigenic/multifactorial

	External references: 5 OMIM references - 1 MeSH reference: D009396		External references: 1 OMIM reference - 1 MeSH reference: D001746

Nephroblastoma		Bladder exstrophy
	Very frequent - Acute abdominal pain / colic - Kidney / renal neoplasm / tumor / carcinoma / cancer - Neoplasms / tumors Occasional - Aniridia / iris hypoplasia - Chronic arterial hypertension - Fever / chilling - Hematuria / microhematuria - Hepatic / liver neoplasm / tumor / carcinoma / cancer - Lung / bronchopulmonary neoplasm / tumor / carcinoma / cancer - Lymphadenopathy / polyadenopathies - Weight loss / loss of appetite / break in weight curve / general health alteration		Very frequent - Anus / rectum anomalies - Bladder / cloacal exstrophy - Clitoris / labia majora / labia minora / female external genitalia hypoplasia - Hypospadias / epispadias / bent penis - Micropenis / small penis / agenesis - Umbilical hernia - Vesicorenal / vesicoureteral reflux Frequent - Inguinal / inguinoscrotal / crural hernia - Recurrent urinary infections - Urethral anomalies / stenosis / posterior urethral valves / megalocystis Occasional - Encopresis / fecal incontinence - Intestinal / gut / bowel malrotation - Omphalocele / exomphalos - Short bowel